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童宇茹


姓名:童宇茹

性别:女

职称:副教授


招生院所:太阳集团tyc4633


招生类型:科学学位(硕、博)


招生专业:药物分析学(科学学位)


研究方向名称:中药活性成分生物合成途径解析和合成生物学研究


电子信箱:tongyuru@ccmu.edu.cn


个人简介

童宇茹博士,2019年进入首都医科大学,主要讲授《天然药物化学》、《分子生药学》、《无机及分析化学实验》等课程。长期从事中药资源和分子生药学研究,目前以第一或通讯作者在Angew. Chem. Int. Edit、Plant Biotech. J.等高水平杂志发表SCI论文13篇,中文核心期刊7篇,参编专著1部,申请中国专利4项,授权中国专利2项、美国专利1项,H指数16(web of science)。担任中国植物学会药用植物及植物药专业委员会青年委员,Science of Traditional Chinese Medicine 杂志青年编委,获得省部级一等奖、二等奖各一项。主持国家自然科学基金青年项目、国家重点研发计划、国家重点研发计划子课题等项目。

主要研究包括以下2个方向

(1)中药活性成分生物合成途径解析和酶的定向改造

(2)中药合成生物学研究

教育经历

2009.9-2013.7,首都医科大学 中医太阳集团tyc4633中药学学士

2013.9-2016.7,首都医科大学 中医太阳集团tyc4633中药学硕士

2016.9-2019.7,沈阳药科大学 中太阳集团tyc4633中药学博士

工作经历

2019.8-2021.12,首都医科大学太阳集团tyc4633 讲师

2022.1-至今,首都医科大学太阳集团tyc4633 副教授

重要学术论文:

[1]Siyu Shen, Yuqing Wu, Yunfeng Luo, Yang Li, Wei Gao, Luqi Huang, Yating Hu *, Kang Chen *, Yuru Tong*. The Dynamic Changes in Biosynthesis and Spatiotemporal Distribution of Phytohormones Under Jasmonic Acid Treatment Provide Insights into Hormonal Regulation in Sinopodophyllum hexandrum. Plants. 2025, 14(7):1001.

[2]Yuru Tong*, Kang Chen, Zhou-Qian Jiang, Li-Chan Tu, Yun-Feng Luo, Han Zheng, Ya-Qiu Zhao, Si-Yu Shen, Ya-Ting Hu, Wei Gao*. Spatiotemporal expression analysis of jasmonic acid and saponin-related genes uncovers a potential biosynthetic regulation in Panax notoginseng. Journal of the Science of Food and Agriculture.2024,104(15):9772–9781.

[3]Yunfeng Luo#, Xiaoli Ma#, Yufan Qiu#, Yun Lu, Siyu Shen, Yang Li, HaiyunGao, Kang Chen, Jiawei Zhou, Tianyuan Hu,Lichan Tu, Huan Zhao, Dan Li, Faqiang Leng,Wei Gao, Tao Jiang, Changli Liu*, Luqi Huang*, Ruibo Wu*, Yuru Tong*. Structural and Catalytic Insightinto the Unique Pentacyclic Triterpene Synthase TwOSC, Angewandte Chemie International Edition, 2023.

[4]Yuru Tong#, Xiaoli Ma#, Tianyuan Hu, Kang Chen, Guanghong Cui, Ping Su, Haifeng Xu, Wei Gao* Tao Jiang* Luqi Huang*. Structural and mechanistic insights into the precise product synthesis by a bifunctional miltiradiene synthase. Plant Biotechnology Journal. 2023, 21(1): 165-175.

[5]Jiahua Feng, Kang Chen, SiyuShen, Yunfeng Luo, Xihong Liu, Xin Chen, Wei Gao, Yuru Tong*. The composition, pharmacological effects, related mechanisms and drug delivery methods of alkaloids from Corydalis yanhusuo. Biomedicine & Pharmacotherapy. 2023, 167,115511.

[6]Yuru Tong#*, Tianyuan Hu#, Lichan Tu, Kang Chen, Tiezheng Liu, Ping Su, Yadi Song, Yuan Liu, Luqi Huang*, Wei Gao*.Functional characterization and substrate promiscuity of sesquiterpene synthases from Tripterygium wilfordii. International journal of biological macromolecules. 2021, 185: 949–958.

[7]Yuru Tong#, Yunfeng Luo#, Wei Gao*. Biosynthesis of paclitaxel using synthetic biology. Phytochemistry Reviews 2021, 21:863-877.

[8]Yuru Tong#, Yifeng Zhang#,Yujun Zhao, Tianyuan Hu, Jiadian Wang, Luqi Huang*, Wei Gao*.Differential expression of the TwHMGS gene and its effect on triptolide biosynthesis in Tripterygium wilfordii.Chinese Journal of Natural Medicines.2019.17(8).575-584.

[9]Yuru Tong, Ping Su, Hong-yu Guan, Tian-yuan Hu, Jin-long Chen, Yi-feng Zhang, Yu-jun Zhao, Lin-hui Gao, Xia-nan Zhang, Lu-qi Huang*, Wei Gao*.Eudesmane-type sesquiterpene diols directly synthesized by a sesquiterpene cyclase in Tripterygium wilfordii.Biochemical Journal.2018.475 (17).2713-2725.

[10]Ping Su#, Yuru Tong#, Qiqing Cheng, Yating Hu, Meng Zhang, Jian Yang, Zhongqiu Teng, Wei Gao*, Luqi Huang*.Functional characterization of ent-copalyl diphosphate synthase, kaurene synthase and kaurene oxidase in the Salvia miltiorrhiza gibberellin biosynthetic pathway.Scientific reports.2016.6.23057.

[11]Yuru Tong, Meng Zhang, Ping Su, Yujun Zhao, Xiujuan Wang, Xia-nan Zhang, Wei Gao*, Lu-Qi Huang*..Cloning and functional characterization of an isopentenyl diphosphate isomerase gene from Tripterygium wilfordii. Biotechnology & Applied Biochemistry.2016. 63 (6).863-869.

[12]Yuru Tong#, Chao Jiang#, Yuan Yuan*, Yan Jin, Zhanhu Cui, Luqi Huang*. Molecular identification of antelope horn by melting curve analysis, Mitochondrial DNA Part A, 2016, 27(6): 3945-3951.

[13]Yuru Tong, Ping Su, Yujun Zhao, Meng Zhang, Yujia Liu, Xiujuan Wang, Xiannan Zhang, Wei Gao*, Luqi Huang *. Molecular cloning and characterization of DXS and DXR genes in terpenoid biosynthetic pathway from Tripterygium wilfordii. International Journal of Molecular Sciences.2015.16(10).25516-25535.

承担重要项目

2023YFC3404900, 科技部国家重点研发计划,主持,200万,2023-2025

2020YFA0908003,科技部国家重点研发计划课题三子课题,主持,32.94万,2021-2025

82003894,国家自然科学基金青年项目,主持,24万,2021-2023

2060302,中央本级重大增减支项目(子课题),主持,40万,2025-2026

首都医科大学优秀青年B类项目,主持,90万,2025-2027

重要奖项

中国中西医结合学会, 科学技术奖,一等奖(本人排名13/17),2024

中华中医药学会, 科技技术奖,二等奖(本人排名6/11),2022

首都医科大学,科学技术奖,三等奖(本人排名1/6),2023

首都医科大学,科学技术奖,二等奖(本人排名4/8),2021

首都医科大学青年学者绿色招生通道计划,2024




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